Ukutholakala okusha mayelana nesidoda kungathuthukisa ukuzala nezindlela zokuvimbela inzalo
(Medical Xpress)—Ucwaningo olusha olwenziwe ososayensi baseCornell lwathola ukuthi ingxenye yesendlalelo sesidoda ilawula ngokuqinile isinyathelo esibalulekile ekufundiseni, okwenza kube yithagethi ebalulekile kwemizamo yokusiza ukuvundisa noma ukukuvimbela.
Lokho kuyindaba enhle kokubili emizamweni yokwanda kokuzala nasekuthuthukisweni kwemithi yokuvimbela inzalo, ngokusho kombhali ohola lolu cwaningo uDkt. Alexander Travis, onguprofesa omunye kwezokuzalana eBaker Institute for Animal Health eCornell naseCollege of Veterinary Medicine.
Yena nozakwabo babika kumagazini Developmental Cell ukuthi njengoba isidoda sisondela eqandeni, i-GM1 esendlalelweni sesidoda ilawula ukuvuleka nokuvaleka kwesiteshi esithile se-calcium ebusweni bekhanda lesidoda, okwenza inani elincane le-calcium lingene esidodeni. Abacwaningi babika ukuthi lokhu kunyakaza okuncane kwe-calcium kumele kuqedwe ukuze isidoda sikwazi ukukhulula ama-enzyme asisiza ukuthi sidlule kwingqimba yangaphandle ewugqinsi yeqanda. Lo msebenzi wokukhululwa, obizwa ngokuthi i-acrosome exocytosis, uyisinyathelo esingabuyiseki esiye ngqo ekuvundiseni.
UkuBaluleka kwe-Calcium ne-GM1
“Ngokuchaza ukuthi i-GM1 ilawula kanjani lesi siteshi se-calcium, manje sesingafuna izinto ezivimba noma ezilingisa lowo msebenzi,” kusho uTravis, ophinde abe ngumqondisi wemvelo e-Atkinson Center for a Sustainable Future yaseCornell. “Lokhu kungase kukunike indlela entsha yesidakamizwa se-spermicide,” engeza kanje.
Isidakamizwa sokubulala isidoda (spermicide) esitholakala emakethe njengamanje sisekelwe ku-detergent, okuyindlela eyenza abanye abasebenzisi babe sengozini enkulu yokutheleleka izifo ezithathelwana ngocansi. Uthi indlela entsha ingase isebenze ngaphandle kwama-detergent, ilingise umphumela we-GM1 esidodeni futhi iyivuse ukuthi iqhume ivuleke bese ifa kudala ngaphambi kokuba ifinyelele eqandeni.
Ngakolunye uhlangothi, uthe lolu lwazi lungasiza ekuqondiseni ukuthuthukiswa kwemithi emisha yokugcina isidoda sibandayo (cryopreservatives) esetshenziswa ekwelapheni ukungabi nabantwana kubantu, ezinkomeni noma ezifweni ezisengozini yokushabalala. Ezinye izixube zamanje ze-cryopreservative ziqukethe inhlanganisela zama-lipid, kuhlanganise ne-GM1, okuyingxenye engase ivuse i-acrosome exocytosis kusenesikhathi futhi yehlise isikhathi isidoda esingasinda ngaso ngemva kokuncibilika, kusho uTravis.
Khonamanjalo, uhlelo olusheshayo lokusebenzisa i-GM1 wukuhlolwa kokuzala kwabesilisa. Njengoba ukuba khona nokuma kwe-GM1 esendlalelweni sesidoda kudinga ukulungiswa ngokunembayo ukuze kube nokuvundisa, ukuphazamiseka kulezi zici kungalimaza umsebenzi wesidoda, okwenza i-GM1 ibe uphawu (biomarker) olungele ukukala ukuzala kwabesilisa, kusho uTravis. Inkampani uTravis ayisungule naye abanye, i-Androvia Inc., isithuthukise ukuhlolwa kokuzala kwabesilisa okwamanje okusezigabeni zokuhlolwa kwezokwelapha.
Le miphumela ingase futhi inikeze izimpendulo kwezinye izinkinga ezihlobene nempilo, kwenezela uTravis. Lezi ziteshi ze-calcium ezisebenza esidodeni futhi zilawulwa yi-GM1 zitholakala nezinye izingxenye zomzimba, futhi uTravis uthi ilabhorethri yakhe manje izozihlola ukuthi ingabe ukusebenzisana kwe-GM1 ne-calcium channel abakutholile esidodeni kuyiqiniso yini nakulezo zitho.
Funda lonke lolu cwaningo lapha!
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Eqinisweni, i-Conceive Plus® ukuphela (only) kokokuthambisa okusekela ukuzala (fertility lubricant) okuqukethe ama-ion e-Calcium ne-Magnesium ukusekela ukusimama kwesidoda (sperm viability), ukunyakaza kwesidoda (sperm motility) nenqubo yokuvundisa. Ukusekela ukukwazi ukuzala kuyisigaba esibalulekile ekukhulelweni, kungakhathaliseki ukuthi usaqala noma usuvele uzame isikhathi eside ukukhulelwa. Ukusebenzisa okokuthambisa kokuzala i-Conceive Plus njalo ngesikhathi wena nomlingani wakho nenza ucansi phakathi nesikhathi sakho sokuvundisa kungasiza ukwandisa amathuba okukhokha ingane ngendlela yemvelo.
