I-PCOS Nokuncelisa Ibele: Amathiphu Okuthuthukisa Ukunikezwa Kobisi Lwebebele

I-Polycystic Ovary Syndrome (PCOS) yisimo esivamile samahomoni esithinta abesifazane abaningi ngesikhathi sokuphila kwabo sokuzala. Abesifazane abane-PCOS ngokuvamile baba nokungabekezeleli kahle i-insulin, kanti ukuqongelela kwe-insulin kubhekwa njengimbangela eyinhloko yokuthuthuka kwe-PCOS [1].

Lokhu kungalingani kwamahomoni kungaholela ezimpawini ezahlukene, kuhlanganise nemijikelezo yokuya esikhathini engajwayelekile, ukukhula kwezinwele ngokweqile, izinduna kanye nokuzuza isisindo [2]. I-PCOS ingaphinde yehlise impilo yokuzala futhi inyuse ingozi yezinkinga ngesikhathi nangemva kokukhulelwa kokuqala. Enye yalezo zinkinga owesifazane angase ahlangabezane nazo ngenxa ye-PCOS ubunzima bokuncelisa ibele.

Kulesi sihloko, sizohlola ubudlelwano phakathi kwe-PCOS nokuncelisa ibele futhi sikuholele ekutheni ungawunqoba kanjani ubunzima bokuncelisa ukuze usekele umntwana okhula.

I-PCOS Nezempilo Yokuzala Kwabesifazane

Inhlangano Yezempilo Yomhlaba (WHO) ithi ukuthi i-PCOS ingesinye sezimbangela ezihamba phambili zokungabi nenzalo kwabesifazane [3]. Lesi simo singaphazamisa inqubo evamile yokukhishwa kweqanda, okuwukukhishwa kweqanda ezibindini minyaka yonke. Abesifazane abane-PCOS ngokuvamile baba nemijikelezo yokuya esikhathini engajwayelekile enezindlela zokukhishwa kweqanda ezingajwayelekile.

Ngaphezu kokubangela izinkinga ekukhishweni kweqanda, ukungalingani kwamahomoni ku-PCOS kungase kuthinte nekhwalithi yamaqanda [4]. Lokhu kuqhubeka kulimaza impilo yokuzala futhi kwehlise amathuba okukhulelwa, okwenza kubaluleke ukuthi uqonde incazelo yokukhulelwa nezinto eziyithintayo.

Uma uhlangabezana nezimpawu ze-PCOS noma usuvele uxilongwe ngaleli gciwane, khumbula ukuthi kungenzeka ukulilawula ngemithi kanye nokuguqula indlela yokuphila. Uma ungakwazi ukukhulelwa ngokwemvelo ngenxa ye-PCOS, izindlela zokwelapha ezifana nobuchwepheshe bokuzalisa obusizwa (assisted reproductive technologies) zingakusiza.

Ukuncelisa ibele ne-PCOS

Noma owesifazane enganqoba izinselelo zokuzala ezibangelwa i-PCOS futhi akhulelwe ngempumelelo, impilo ngemva kokukhulelwa nangemva kokukhulelwa ingase iphinde ibe yinselele. Isibonelo, abesifazane abaningi abane-PCOS babhekana nezinkinga ngesikhathi sokuncelisa ibele.

Izifundo zibonise ukuthi i-PCOS inganciphisa ukukhiqizwa kobisi ko-mama abancelisayo [5]. Isizathu esiyinhloko salokhu ukungalingani kwamahomoni, okuphazamisa ikhono lomzimba lokukhiqiza nokukhulula ubisi ngendlela esebenzayo.

Ukungalingani Kwamahomoni Ku-PCOS Kuthinta Kanjani Ukuncelisa?

Amahomoni amabili abalula alawula kakhulu ukukhiqizwa nokukhishwa kobisi lwebele yi-prolactin ne-oxytocin. I-prolactin ivuselela ukukhiqizwa kobisi ezindlaleni zobisi, kanti i-oxytocin isiza ekukhishweni kobisi.

Abesifazane abane-PCOS bavame ukuba nokumelana ne-insulin okuholela emazingeni aphezulu e-insulin nama-androgen. U ucwaningo lwango-2021 ubonisa ukuthi ukumelana ne-insulin kungalimaza kabi amazinga e-hormone i-prolactin egazini [6]. U ucwaningo lwango-2018 ibonisa ukuthi abesifazane abane-PCOS abancelisayo bangaba namazinga aphansi e-oxytocin uma beqhathaniswa nabesifazane abangenayo i-PCOS [7].

Lezi zifundo zichaza ukuthi i-PCOS ingawuthinta ngqo kanjani umqondo wokuncelisa futhi ilimaze ikhono labesifazane lokuncelisa. I-PCOS ingawuthinta nangokungaqondile umncintiswano wokuncelisa ngokudala ukukhuluphala. Izifundo izibonisa ukuthi ukukhuluphala kunomthelela omubi ebudeni besikhathi sokuncelisa, futhi abesifazane abane-BMI ephezulu mancane amathuba okuthi bakhe ukuncelisa okunempumelelo [8].

Ungawunqoba Kanjani Umqansa Wokuncelisa Une-PCOS?

Kungenzeka ukwandisa ukukhiqizwa nokukhishwa kobisi kwabesifazane abane-PCOS abanezinkinga ekunceliseni. Nawa amanye amathiphu angakusiza uthuthukise inani lobisi:

1. Ukuncelisa Kaningi: Izifundo zibonisa ukuthi ukuvuselelwa njalo nokukhipha ubisi ebeleni kungathuthukisa ukukhiqizwa kobisi [9]. Uma ungowesifazane one-PCOS obhekene nenkinga yokukhiqiza ubisi oluncane, kufanele uncelise ingane yakho kaningi ukuze uvuse ukukhiqizwa kobisi.
2. Ukuthintana Isikhumba Ngesikhumba: Izifundo zibonisa ukuthi ukuthinta, ukucindezela ngobumnene, nokufudumala kwandisa ukukhiqizwa kwe-oxytocin [10]. Kumele wengeze ukuthintana kwesikhumba kuya esikhunjeni nengane ukuze uvuse i-oxytocin, okuthuthukisa ukugeleza kwegazi.
3. Indlela Yokuphila Enempilo: Ukukhuluphala kungalimaza ikhono lokuncelisa, okusho ukuthi udinga ukugxila ekugcineni isisindo esinempilo ukuze usekele inqubo yokuncelisa ngemva kokukhulelwa. Imisebenzi yomzimba efana nokuzivocavoca ingakusiza ugcine isisindo esinempilo futhi ikhuthaze ibhalansi yamahomoni ukuze ukuncelisa kube nomphumela omuhle.
4. Imithi Nezithasiselo: Eminye imithi noma izithasiselo zemithi yemvelo ingasiza ukwandisa ukukhiqizwa kobisi lwebele. Nokho, kubalulekile ukubonana nodokotela wakho ngaphambi kokuthatha yinoma yiziphi lezi zithasiselo.

Isiphetho

I-PCOS ingesinye sezimo ezivamile zempilo ezibhekana nazo abesifazane abaningi ngesikhathi sabo sokuzala. Isimo esivame ukuthuthuka ngenxa yokumelana ne-insulin nokwanda kwezinga le-insulin emzimbeni. I-PCOS ingadala izinkinga eziningana, njengokuphazamiseka kokuya esikhathini nokukhuluphala, kodwa olunye udaba abesifazane abaningi abangaluqapheli ukwehla kwamandla okuncelisa.

Ubudlelwano phakathi kwe-PCOS nokuncelisa bubangelwa ukungalingani kwama-hormone okwenzeka emzimbeni ngenxa yale nkinga. I-PCOS ingaphazamisa izinga lama-hormone anjenge-prolactin ne-oxytocin, alawula ukukhiqizwa nokukhishwa kobisi lokuncelisa.

Imithombo esetshenzisiwe

1. Purwar, A., & Nagpure, S. (2022). Ukumelana ne-insulin ku-Polycystic Ovarian Syndrome. Cureus, 14(10), e30351. https://doi.org/10.7759/cureus.30351 
2. Polycystic Ovary Syndrome (PCOS). (2024, December 2). I-Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/8316-polycystic-ovary-syndrome-pcos 
3. World Health Organization: WHO & World Health Organization: WHO. (2023, June 28). I-polycystic ovary syndrome. https://www.who.int/news-room/fact-sheets/detail/polycystic-ovary-syndrome 
4. Chappell, N. R., Barsky, M., Shah, J., Peavey, M., Yang, L., Sangi-Haghpeykar, H., Gibbons, W., & Blesson, C. S. (2020). Ama-embryo avela ezigulini ezine-polycystic ovary syndrome ezinesimo se-hyperandrogenemia afinyelela esigabeni se-morula ngokushesha kunezamaqembu okulawula. F&S Reports, 1(2), 125–132. https://doi.org/10.1016/j.xfre.2020.05.006 
5. Vanky, E., Isaksen, H., Moen, M. H., & Carlsen, S. M. (2008). Ukuncelisa ebeleni kubantu abane-polycystic ovary syndrome. Acta Obstetricia Et Gynecologica Scandinavica, 87(5), 531–535. https://doi.org/10.1080/00016340802007676 
6. Yang, H., Lin, J., Li, H., Liu, Z., Chen, X., & Chen, Q. (2021). I-Prolactin ihlotshaniswa nokumelana ne-insulin nokungasebenzi kahle kwamaseli e-beta kwabesifazane abangenayo inzalo abane-Polycystic Ovary Syndrome. Frontiers in Endocrinology, 12. https://doi.org/10.3389/fendo.2021.571229 
7. Jahromi, B. N., Dabbaghmanesh, M. H., Bakhshaie, P., Parsanezhad, M. E., Anvar, Z., Alborzi, M., Zarei, A., & Bakhshaei, M. (2018). Ukuhlola izinga le-oxytocin, izingxenye zemetabolism ye-glucose namanani okuhlukanisa e-oxytocin ne-anti-mullerian hormone kwabesifazane abangenayo inzalo abane-PCOS. Taiwanese Journal of Obstetrics and Gynecology, 57(4), 555-559. https://doi.org/10.1016/j.tjog.2018.06.015 
8. Ballesta-Castillejos, A., Gomez-Salgado, J., Rodriguez-Almagro, J., Ortiz-Esquinas, I., & Hernandez-Martinez, A. (2020). Ubudlelwano phakathi kwe-body mass index kamama (BMI) nokuqala kokuncelisa nezinselelo ezihambisana nakho: inhlolovo eku-inthanethi. International Breastfeeding Journal, 15(1). https://doi.org/10.1186/s13006-020-00298-5 
9. Cuya, C. M., Barriga, C., Del Carmen Graf, M., Cardeña, M., Del Pilar Borja, M., Condori, R., Azocar, M., & Cuya, C. (2024). Ukuvuselelwa okunemizwa eminingi kanye nomthelela wakhona ekukhiqizweni kobuningi bobisi lwebele kubo omama bezinsana ezizalwe ngaphambi kwesikhathi. Frontiers in Pediatrics, 12. https://doi.org/10.3389/fped.2024.1331310 
10. Bigelow, A. E., & Power, M. (2020). Ukuthintana kwesikhumba nesikhumba phakathi kukamama nosana: Imiphumela yesikhathi esifushane nangesikhathi eside kubo omama nezingane zabo ezizalwe ngesikhathi esigcwele. Frontiers in Psychology, 11. https://doi.org/10.3389/fpsyg.2020.01921