Ucwaningo lubonisa ithemba lokulondoloza ikhono lokuzala kubafana abane-umdlavuza
Ucwaningo lubonisa ithemba lokugcina ikhono lokuzala kubafana abanesifo somdlavuza.
Ososayensi sebesondele isinyathelo ekutheni bakwazi ukugcina ikhono lokuzala kubafana abasebancane abahlinzekwayo nge-chemotherapy nangokwelashwa ngemisebe ngenxa yomdlavuza. Ucwaningo olusha, olushicilelwe kuUkuzala Nokungazali, iphephabhuku le-American Society for Reproductive Medicine, lubheka ukuphepha kwenketho ososayensi abayithuthukiselayo abafana abangakafiki ekuvuthweni ngokocansi futhi abangakwazi ukubeka isidoda ebhange.
Ososayensi bahlose ukufriza isampula yesicubu samatshwele abafana ukuze lapho sebefinyelela ebudaleni, amaseli esiqu e-spermatogonial (SSCs) atholakala kuleso sicubu akwazi ukwandiselwa bese efakelwa emuva ezigulini. Lawa maseli anesibopho sokukhiqizwa kwesidoda kukho konke ukukhula komuntu omdala.
"Ucwaningo lwethu lubhekane nodaba olubalulekile lokuphepha – ukuthi ingabe amaseli omdlavuza angase abe khona kumasampula esicubu samatshwele ayasinda yini enqubweni esetshenziselwa ukuphindaphinda amaseli esiqu akhiqiza isidoda," kusho umbhali ohola ucwaningo uHooman Sadri-Ardekani, M.D., Ph.D., uthisha emkhakheni we-urology kanye ne-regenerative medicine e-Wake Forest Baptist Medical Center.
"Lokhu kuyinto okufanele icatshangelwe ngenxa yamathuba okuthi umdlavuza uphinde ufakwe emzimbeni wesiguli," esho kanje. "Ucwaningo, oluhilele enye yezifo zomdlavuza ezingamahlalakhona ezinganeni, lubonise ukuthi amaseli omdlavuza aqedwe ngokuphelele. Ngokusekelwe kule mibiko, sincoma ukuthi bonke abafana abanesifo somdlavuza banikwe ithuba lokugcina isicubu samatshwele ukusetshenziswa kwezokwelashwa okungenzeka esikhathini esizayo.
" USadri-Ardekani wenza lolu cwaningo ebambisene nocwaningo e-University of Amsterdam nase-Avicenna Research Institute eTehran, e-Iran, ngaphambi kokuzimbandakanya ne-Wake Forest Baptist.
Izinhlobo zomdlavuza ezingaba sengozini enkulu yokungabi nenzalo, kuye ngokwelashwa, zihlanganisa ezinye izinhlobo ze-leukemia, isifo sika-Hodgkin, umdlavuza wobuchopho nomdlavuza wamathambo. Ngenxa yamazinga aphezulu okusinda komdlavuza wezingane – acishe afinyelele ku-80 pesenti – iziguli eziningi zomdlavuza kunangaphambili sezifika ebudaleni futhi eziningi zibhekana nezinkinga zokungazali.
Ucwaningo lwamanje luhilele amaseli e-acute lymphoblastic leukemia (ALL), uhlobo lomdlavuza oluvamile ezinganeni. Ucwaningo lwangaphambilini lwalukhombisile ukuthi kuze kufike ku-30 pesenti wabafana abane-ALL babenamaseli omdlavuza esicutshini samatshwele abo.
Izifundo eziningi zangaphambilini zizame ukucekela phansi amaseli omdlavuza esicutshini se-biopsy, kodwa zinikeze imiphumela ephikisanayo. Indlela kaSadri-Ardekani nozakwabo bekuwukuhlola ukuthi ingabe amaseli omdlavuza angasinda yini enqubweni yase-labhorethri abayithuthukisile yokuphindaphinda ama-SSC asuka ku-biopsy encane yesicubu. Le nqubo yandisa ama-SSC okuqala ngezinga eliphindwe izikhathi ezingu-18 000 ukuze kube namaseli anele okufakelwa emuva esigulini lapho sesifinyelele ebudaleni.
Ngalesi sikhathi socwaningo, amaseli e-ALL athathwa kumnkantsha wamathambo eziguli ezintathu. Ithimba lase lifaka amaseli e-ALL yedwa, kanye namaseli e-ALL ahlanganiswe namaseli esicubu samatshwele, enqubweni yokuphindaphinda amaseli.
Noma ngabe amaseli e-ALL ayengama-40 pesenti wezingxube zamaseli ayephiliswa, aqedwa ngokuphelele zingakapheli izinsuku ezingu-26 zokuphila esikhiqizweni.
"Lolu cwaningo lokuqala lubonise ukuthi uhlelo lokuphila kwamaseli alwakhelwe aluvumelanga kuphela ukwanda kahle kwamaseli esiqu e-sidoda, kodwa futhi luqede amaseli e-ALL," kusho uSadri-Ardekani. Uthe ukufakelwa kwama-SSC akukazanywanga kubantu, kodwa sekuye kwenziwa ngempumelelo ezinhlotsheni eziningana zezilwane, kuhlanganise nezinkawu.
Uphawule ngokuthi ngaphambi kokuthi odokotela nososayensi baqale ukunikeza ukufakelwa kwama-SSC ezigulini, kuzodingeka olunye ucwaningo, kuhlanganise nokuhlola ukuthi ingabe nezinye izinhlobo zamaseli e-leukemia nazo zingaqedwa yini enqubweni yokwandisa amaseli.
