Kufanele ukhethe nini amavithamini okukhulelwa anefolate, hhayi i-folic acid?

Abanye omama abakhulelwe abaningi badinga izithasiselo ze-prenatal ukuze basekele ukukhulelwa kwabo. Lezi zithasiselo zokudla zinikeza amavithamini namaminerali abalulekile ekuthuthukisweni komntwana nasekuphileni kukamama. Phakathi kwezakhi eziningi ezisezithasiselweni ze-prenatal, i-folate idlala indima ebalulekile ekuvimbeleni iziphambeko zokuzalwa nasekusekeleni ukukhula kombungu [1].

Nokho, kukhona ukudideka okuvamile kubantu mayelana nezindlela ze-folate. Abantu abaningi bacabanga ukuthi i-folate ne-folic acid yifomu elifanayo le-vitamin B9. Nokho, womabili ayizinhlobo ezihlukene ze-vitamin B9, futhi abanye besifazane ikakhulukazi badinga ama-prenatal ane-folate hhayi i-folic acid njengomthombo we-vitamin B9.

Umehluko Phakathi kwe-Folate ne-Folic Acid

I-folate iyifomu lemvelo le-vitamin B9 elitholakala ekudleni okunjengotamatisi abanoluhlaza, ubhontshisi, nasezithelweni ze-citrus. I-folic acid, ngakolunye uhlangothi, iyinguqulo eyenziwe umuntu esetshenziswa ezifakeni zokudla nakudlela okuqiniswe ngamavithamini [2].

Noma ungathola i-vitamin B9 kuzo zombili lezi zinhlobo, zehluka ngendlela umzimba ozisebenzisa ngayo. I-folate kulula ukuba umzimba uyimunce futhi ayisebenzise. Ngakolunye uhlangothi, umzimba wakho udinga ukuguqula i-folic acid ibe ifomu elisebenzayo elibizwa nge-methyl-tetrahydrofolate (5-MTHF) ngaphambi kokuyisebenzisa kunoma iyiphi imisebenzi [2].

Indlela Umzimba Oguqula Ngayo I-Folic Acid Uyenze I-Folate Esebenzayo?

Lapho udla i-folic acid ekudleni okuqiniswe ngamavithamini noma ezifakeni zokudla, umzimba wakho usebenzisa i-enzyme ukuyiguqula ibe yi-5-MTHF, okuyifomu elisebenzayo le-folate. Nokho, akuwona wonke umuntu ongakwazi ukuguqula kahle i-folic acid iye ku-5-MTHF.

Abanye abantu banenhlobonhlobo yofuzo ku-gene i-MTHFR, enciphisa ikhono labo lokuguqula i-folic acid ibe ifomu layo elisebenzayo [3]. Ezimweni ezinjalo, kuwumqondo omuhle ukukhetha izithasiselo ze-prenatal eziqukethe i-5-MTHF. Ngale ndlela, bazothola ifomu elisebenzayo ngqo, okususela isidingo sokuguqulwa.

Indima Ye-Folate Ngesikhathi Sokukhulelwa

Owesifazane okhulelwe udinga cishe u-600 mcg we-folate nsuku zonke ukuze kusekelwe ukukhula kahle komntwana asesiswini [4]. Isiza ukwakheka kwe-shubhu lezinzwa, eliba ubuchopho nengxenye yomgogodla wengane.

Ucwaningo lubonisa ukuthi ukushoda kwe-folate ngesikhathi sokukhulelwa kungakhuphula ingozi yeziphene zeshubhu lezinzwa enganeni, kuyilapho izithasiselo ze-folic acid zitholakala zisebenza kahle ekuvimbeleni iziphene zeshubhu lezinzwa [1]. Ibuyisela futhi ekukhuliseni i-placenta nasekukhiqizweni kwamaseli egazi abomvu, iqinisekisa ukuthi kokubili umama nengane bathola umoya-mpilo (oxygen) abawudingayo.

Ungakhetha Kanjani Isithasiselo Se-prenatal Esine-Folate?

Lapho uthenga i-prenatal, funa amalebula akhombisa ukuthi aqukethe "methylated folate" noma "5-MTHF." Lokhu kukhombisa ukuthi ifomu elisebenzayo le-folate likhona kuleso sithasiselo.

Uma udokotela wakho ethola ukuthi umzimba wakho awunawo amandla okuguqula i-folic acid ibe i-folate, kufanele ukhethe amavithamini e-prenatal ane-folate hhayi i-folic acid njengomthombo we-vitamin B9. Hlala uthintana nochwepheshe wakho wezempilo ngaphambi kokuqala noma yisiphi isithasiselo ukuze uqinisekise ukuthi sihambisana nezidingo zomzimba wakho.

Kulungile yini ukuthatha i-prenatal vitamin engena-folic acid?

Ungakhetha amavithamini e-prenatal angenayo i-folic acid inqobo nje uma equkethe ifomu elisebenzayo le-folate, njenge-methylated folate noma i-5-MTHF. Lawa mafomu kulula ukuthi umzimba uwasebenzise ngoba umzimba wakho awudingi ukwenza noma yikuphi ukuguqulwa.

Kubantu abanokwehluka kofuzo okuvimba ukuguqulwa kwe-folic acid kube i-folate, izithasiselo eziqukethe i-folate kuphela zingaba inketho ephephe kakhulu nephumelela kangcono. Nokho, qiniseka ukuthi ugwema lezo zithasiselo ezingahlinzeki nhlobo nganoma iyiphi ifomu le-folate. Lokhu kungenxa yokuthi amavithamini e-prenatal angenayo i-folic acid akhuphula ingozi yokushoda kwe-vitamin B9 kanye nezingqinamba ezihambisana nalokho.

Okubalulekile

Ama-supplement ahlukene okukhulelwa eza nezakhiwo ezingafani. Amanye anikeza i-vitamin B9 ngendlela ye-folate, kanti amanye aqukethe le vithamini ngendlela ye-folic acid. I-folate iwuhlobo olusebenzayo lwe-vitamin B9, okusho ukuthi umzimba wakho uyakwazi ukuyisebenzisa ngokuqondile.

Ngokuphambene nalokho, i-folic acid iwuhlobo olungasebenzi lwe-vitamin B9, futhi umzimba wakho uyiguqula uyenze ifomu elisebenzayo ukuze ukwazi ukuyisebenzisa. Kulungile ngokuphelele kwabesifazane abaningi ukuthatha ama-supplement okukhulelwa aqukethe i-folic acid. Nokho, kwabesifazane abanezinguquko zofuzo ezenza bangakwazi ukuguqula i-folic acid ibe yifomu elisebenzayo, i-prenatal ene-folate hhayi i-folic acid iyinketho enconyiwe. Kubomama abahamba esikhathini sangemva kokubeletha, ukucatshangelwa wama-prenatal ngesikhathi sokuncelisa ibele kungaqinisekisa ukusekelwa kokudla okunomsoco okuphelele enganeni nomama.

Izinsiza Ezisetshenzisiwe

1. Greenberg, J. A., Bell, S. J., Guan, Y., & Yu, Y. (n.d.-d). Ukwengeza i-folic acid nokukhulelwa: okungaphezu kokuvimbela nje ukungasebenzi kahle kwe-neural tube. https://pmc.ncbi.nlm.nih.gov/articles/PMC3218540/ 
2. Carboni, L. (2022, July 1). I-folate esebenzayo uma iqhathaniswa ne-folic acid: Indima ye-5-MTHF (Methylfolate) empilweni yomuntu. https://pmc.ncbi.nlm.nih.gov/articles/PMC9380836/ 
3. Hiraoka, M., & Kagawa, Y. (2017). Ukuhlukahluka kwezakhi zofuzo nesimo se-folate. Congenital Anomalies, 57(5), 142–149. https://doi.org/10.1111/cga.12232 
4. Barchitta, M., Maugeri, A., Lio, R. M. S., Favara, G., La Mastra, C., La Rosa, M. C., & Agodi, A. (2020). Ukudla okune-folate nokwengeza kwe-folic acid phakathi kwabesifazane abakhulelwe abasuka eNingizimu ye-Italy: Ubufakazi obuvela ku “Mamma & Bambino” Cohort. International Journal of Environmental Research and Public Health, 17(2), 638. https://doi.org/10.3390/ijerph17020638