Isithasiselo se-Chiro Inositol sempilo yokuzala yabesifazane

Ibhalansi yamahomoni ingesinye sezinto eziyinhloko ezinquma impilo yokuzala yabesifazane namathuba okokukhulelwa. Abesifazane abanokungalingani kwamahomoni bathatha izinhlobo ezahlukene zezithasiselo ukuze bathuthukise ibhalansi yamahomoni kanye nempilo yokuzala.

Esinye isithasiselo esidume kakhulu ngezinzuzo zaso ekuzaleni kwabesifazane i-D chiro inositol supplement. Lesi sithasiselo siqukethe i-inositol engase isekele ukuzala kwabesifazane, ithuthukise ibhalansi yamahomoni kanye nempilo yokuzala iyonke [1].

Kulesi sihloko, sizohlola izinto ezahlukene zomuthi wesithasiselo i-chiro inositol, izinhlobo zawo, ukusetshenziswa kwawo, nemiphumela emibi engase ibe khona. Lesi sihloko siphinde sihlanganise namanye amathiphu okuthuthukisa impilo yokuzala ngendlela yemvelo.

Iyini i-Inositol?

I-Inositol iyikhompawundi etholakala ngokwemvelo ehlobene nomndeni wamavithamini B, yize le khompawundi ingakaklonyeliswa ngokusemthethweni njengevithamini [1]. Ikhona ngezinhlobo ezahlukene, kodwa i-myo-inositol ne-D chiro inozytol yizona ezinucwaningwe kakhulu futhi ezisetshenziswa kabanzi.

Ungawathola la makhompawundi ngokudla ukudla okunempilo okulinganiselayo, okuhlanganisa izithelo, ubhontshisi, okusanhlamvu, namantongomane [2]. Nokho, abanye abantu bangase bangawatholi ngokwanele la makhompawundi ekudleni kwabo. Ezimeni ezinjalo, izithasiselo zisiza ukugcwalisa lezo zikhala ekudleni [3]. Izinhlobo zale khompawundi ezitholakala njengesithasiselo zifaka i-inositol powder nama-inositol tablets. Uma unelukuluku mayelana nesikhathi esithathayo ukubona imiphumela, ungafunda kabanzi ngokuthi kuthatha isikhathi esingakanani i-myo-inositol ukuthi iqale ukusebenza nalokho ongakulindela ngesikhathi usebenzisa lesi sithasiselo.

Yiziphi Ezehlukene Izinhlobo ze-Inositol?

I-Inositol iza ngezinhlobo eziningana, kodwa lezo ezisetshenziswa kakhulu ngenxa yezinzuzo zazo empilweni i-myo-inositol ne-D-chiro inositol. Inhlanganisela yalezi ezimbili nayo ikhona, futhi lokho kubizwa ngokuthi i-Myo D. Nansi incazelon ezinhlotsheni eziningi ze-inositol:

1. Myo-Inositol

I-myo inositol yifomu elivame kakhulu le-inositol emzimbeni. Libamba iqhaza elibalulekile ezinqubweni eziningi zeseli, ikakhulukazi lezo ezihlobene nokusebenza kwe-insulin. Ngokuthuthukisa indlela umzimba osetshenziswa ngayo i-insulin, i-myo-inositol ingasiza ukulawula amazinga kashukela egazini futhi isekele ibhalansi yamahomoni [4].

Ikhono le-inositol lokulawula ushukela egazini ngokuthuthukisa ukumelana ne-insulin lingaba usizo kakhulu kwabesifazane abane-PCOS ngoba ukumelana ne-insulin kuyinkinga evamile kwabesifazane abane-PCOS.

2. I-D-chiro Inositol

I-D-chiro inositol iphinde isebenze kanye ne-myo-inositol ukuthuthukisa ukuzwela kwe-insulin. Ithuthukisa ukusabela komzimba wakho ku-insulin, okunganciphisa izimpawu zokungalingani kwamahomoni. I-D chiro inositol ayivamile njenge-myo-inositol emzimbeni, kodwa idlala indima ebaluleke ngokulinganayo ekugcineni impilo yamahomoni neyokugaya umzimba.

Ucwaningo luka-2023 olwenziwe yi-Journal of Clinical Medicine lwabonisa ukuthi ukwelashwa kwezinyanga eziyisithupha ngezithasiselo ze-D-chiro inositol kwehlise i-body mass index futhi kwathuthukisa ukuzwela kwe-insulin kwabesifazane [5].

Izinzuzo ze-Chiro Inositol Kwabesifazane

Nawa amanye amabhonasi aqinisekiswe ngesayensi e-Inositol kwabesifazane:

1. Ukulingana Kwamahomoni

Ukungalingani kwamahomoni kungadala izinkinga ezifana nemijikelezo yokuya esikhathini engajwayelekile, okwenza kube nzima ukuthola i-ovulation nokuhlela ucansi ngendlela efanele. Lokhu kwehlisa kakhulu aamathuba okukhulelwa kowesifazane. Ukungalingani kwamahomoni kungadala futhi isifo sobuso (acne) nokushintshashintsha kwesimo sengqondo.

I-Inositol yokulinganisa amahomoni iyindlela esebenzayo, kanti nezifundo zesayensi zisekela indima ewusizo ye-inositol ekulinganiseni amahomoni. Ucwaningo luka-2016 lukhombisa ukuthi ukuthatha izithasiselo ze-inositol kunganciphisa izimpawu zokungalingani kwamahomoni kwabesifazane futhi kuthuthukise impilo yokuzala jikelele [6].

2. Ukusekela Ukuzala Kwabesifazane

Kwabesifazane trabazama ukukhulelwa, ukulingana kwamahomoni nge-inositol kubaluleke kakhulu. Izithasiselo ze-Inositol eziqukethe u-2000mg we-inositol zingathuthukisa ikhwalithi yamaqanda, i-ovulation, nokuzala konke. Umphumela wokubambisana we- myo inositol ne-D chiro inositol kusiza ukudala indawo lapho amathuba okukhulelwa ephezulu khona kakhulu.

U ucwaningo luka-2021 eshicilelwe ku-National Library of Medicine ikhombisa ukuthi ukuthatha isithasiselo se-inositol kuthuthukisa izinga lokukhulelwa kwabesifazane abangakhuleli abahlinzekwa ukwelashwa kokuzala njengokuthi i-IVF [7].

3. Ukulawula i-PCOS

I-PCOS ingenye yezinkinga ezivamile zokuzala kwabesifazane ngesikhathi sabo sokuzala. Lesi simo sichazwa ukuya esikhathini okungajwayelekile, ukukhula kwezinwele ngokweqile, nobunzima bokukhulelwa.

Ucwaningo lukhombisa ukuthi isithasiselo esingcono kakhulu se-myo inositol ne-d-chiro inositol singathuthukisa kakhulu lezi zimpawu ku-PCOS [6]. I-Inositol isebenza ngokuthuthukisa ukuzwela kwe-insulin, okuyinkinga eyinhloko ku-PCOS.

4. Isimo Sengqondo Nempilo Yengqondo

Njengoba ukungalingani kwamahomoni kunikela kakhulu ekushintsheni kwesimo sengqondo, i-Inositol ingaba nemiphumela emihle kwesimo sengqondo nempilo yengqondo ngokuthuthukisa ukulingana kwamahomoni.

Ukungalingani kwamahomoni kungaba imbangela enkulu yokukhathazeka nokudangala. Ngakolunye uhlangothi, i-inositol ingase isekele inhlalakahle yengqondo futhi ithuthukise izimpawu ezihlobene nesimo sengqondo.

Izinhlobo Zezithasiselo Ze-Inositol

Ungakwazi uthole izithasiselo ze-inositol ngendlela yamaphilisi noma umgubo. Zombili lezi zinhlobo zinamaphuzu azo amahle kanye namabi. Ezinye izifazane zikhetha ukuthatha amaphilisi ngoba akalelwe ngaphambili futhi kulula ukuwathatha uhamba.

Ngakolunye uhlangothi, ezinye izifazane zithola kunzima ukuthatha amaphilisi njalo futhi zikhetha ukuthatha i-inositol ngendlela yomgubo. Lolu hlobo lomgubo lungaxutshwa neziphuzo futhi lukuvumela ukuthi ukhethe umthamo othanda ukuwuthatha ngaphakathi kwemingcele ephephile.

Iyiphi Umthamo Onconyiwe We-Inositol?

Isibindi nezinyongo zakho zikhiqiza inani elithile le-inositol nsuku zonke kususelwa kokudla okuthile. Lokhu kudla kuhlanganisa inyama, izithelo, ubhontshisi, okusanhlamvu nama-legume. Kwezinye izifazane, i-inositol ekhiqizwa emzimbeni yanele ukusekela imisebenzi ebalulekile efana nokuzwela kwe-insulin nokulawulwa kwamahomoni.

Nokho, kuye ngokudla kwakho nenhlalakahle yomzimba jikelele, kungase kungenzeki ukuthi umzimba wakho ukhiqize i-inositol eyanele izidingo zawo. Kulowo mbandela, ukusebenzisa i-inositol njengesithasiselo kuyindlela enconyiwe. Izibiko ziphakamisa ukudla amagremu angu-1 kuya ku-4 e-inositol nsuku zonke, ongawathola ngokuhlanganisa ukudla okulinganiselayo nezithasiselo ze-inositol [8].

Ukukhetha Isithasiselo Se-Inositol Esingcono Kakhulu

Uma ufuna ukuthenga i-myo inositol, kufanele ukhethe imikhiqizo enegama elihle lapho uthenga i-inositol ukuze uqinisekise ukuthi uthola imikhiqizo yekhwalithi. Ungathenga izithasiselo ze-inositol ngokuzimela noma ngaphakathi kwezithasiselo zokuzala kwabesifazane.

Isibonelo, Conceive Plus Ukusekela Ukuchumisa iyisithasiselo sokuzala esihlinzeka ngazo zombili izinhlobo ze-inositol: i-myo-inositol ne-chiro inositol. Kanye ne-inositol, lezi zithasiselo zihlinzeka nangeminye imisoco ebalulekile yokuzala kwabesifazane, kuhlanganise ne-CoQ10 ne-folic acid ukusekela umjikelezo wakho wemvelo wokuchuma.

Kungani Kuhlanganiswa I-Myo Inositol Ne-D Chiro Inositol?

Ucwaningo lubonisa ukuthi ukuhlanganisa lezi zinhlobo ezimbili ngesilinganiso esithile kukopisha isilinganiso sazo semvelo emzimbeni [9]. Lokhu kuhlanganiswa, okuvame ukubizwa ngokuthi i-Myo D, kusebenza kakhulu ekubhekaneni nokungalingani kwamahomoni nasekusekeleni ukuzala. Isengezo esingcono kakhulu se-myo inositol ne-d chiro inositol sivame ukuhlinzeka ngalezi zinhlobo ngesilinganiso esingu-40:1.

Imiphumela Engase Ibe Khona Ekuthatheni I-Inositol

I-inositol ivamise ukuphephile kubantu abaningi. Abanye besifazane bangase babe nemiphumela emibi evela ezifakamisweni ze-inositol njengokungakhululeki okuncane emathunjini. Nokho, le miphumela emibi ivame ukwenzeka kuphela uma uqala ukuthatha izithasiselo okokuqala. Futhi le miphumela imfishane futhi ingenziwa yagwenywa ngokulandela imihlahlandlela efana nokuthatha lezi zithasiselo ngesikhathi sokudla hhayi esiswini esingenalutho.

Kuhlale kuyisinyathelo esihle ukuxhumana nochwepheshe wezempilo noma uchwepheshe wokuzala ngaphambi kokuqala noma yisiphi isithasiselo esisha sempilo yokuzala. Lokhu kubhekwa kubaluleke kakhulu uma ukhulelwe, uncelisa, noma unezinye izifo eziyisisekelo.

Amathiphu Okuthuthukisa Impilo Yokuzala Kwabesifazane

Yize izithasiselo ezifana ne-inositol zizuzisa, abanye besifazane bafuna izindlela zemvelo zokuthuthukisa ukulingana kwama-hormone nempilo yokuzala. Nansi eminye imihlahlandlela engasiza abesifazane bathuthukise amandla abo okukhiqiza inzalo ngendlela yemvelo:

1. Gcina Ukudla Okulinganiselayo: Ukushoda kokudla okunomsoco kungafaka isandla kakhulu ekungasebenzi kahle kokulawulwa kwama-hormone kubobabili abesilisa nabesifazane. Kufanele udle ukudla okulinganiselayo okuhlanganisa izinhlobo ezahlukene zezithelo, imifino, okusanhlamvu okuphelele, namaprotheni anesikhumba esincane samafutha. Lokhu kudla kucebe ngama-antioxidant, i-folic acid, i-calcium, ama-omega-3 fatty acids nezinye izakhi ezondlayo ezisekela impilo yokuzala [10].
2. Lawula Ingcindezi: Ingcindezi ehlala isikhathi eside ingesinye sezizathu ezinkulu zokungalingani kwama-hormone. Ukuzilolonga izindlela zokuphumula ezifana ne-yoga, ukucabangisisa, noma ukuzivocavoca ukuphefumula okujulile kunganciphisa kakhulu ingcindezi futhi kuthuthukise inhlalakahle yengqondo.
3. Ukulala Okwanele: Ukulala kahle kusekela imisebenzi eminingi yomzimba, kuhlanganise nokulawulwa kwama-hormone. Ochwepheshe batusa amahora angu-7 kuya kwayi-8 okulala okuhle ebusuku kubantu abadala ukuze kusekelwe ukusebenza okuvamile komzimba.
4. Gwema Utshwala: Ukusebenzisa utshwala kuyingozi enkulu empilweni yokuzala kowesifazane. Ucwaningo lukhombisa ukuthi ukuphuza utshwala kungaphazamisa amazinga e-estrogen ne-progesterone, okuyiwo ma-hormone amabili abalulekile ekuzaleni alawula umjikelezo wokuya esikhathini [11].
5. Landelela isikhathi sokuvuthwa kweqanda: Ukulandela isikhathi sokuvuthwa kweqanda kubhekisela ekunqumeni kahle izinsuku zakho zokuvuthwa kweqanda, okubaluleke kakhulu kwabesifazane abahlushwa wukungabi nenzalo. Uma owesifazane eyazi izinsuku zakhe zokuvuthwa kweqanda, angakhulisa kakhulu amathuba akhe okukhulelwa ngokuhlela ucansi kulezo zinsuku.

Okubalulekile ekugcineni

Isithasiselo se-chiro inositol siyindlela ethandwayo kwabesifazane abafuna ukuthuthukisa amandla abo okukhiqiza inzalo kanye nempilo yama-hormone. Siqukethe i-inositol, okuyinto okufakazelwe ngokwesayensi ukuthi ithuthukisa ukulawulwa kwama-hormone kanye nezimo ezifana ne-PCOS. Ungakhetha ukuthatha i-chiro inositol ngezindlela ezahlukene ezifaka phakathi ufulawa we-inositol, ufulawa we-myo inositol, namaphilisi e-inositol.

Ukuze uthole imiphumela emihle kakhulu, cabanga ngesengezo se-myo Inositol ne-D chiro inositol esesilinganisweni esinconyiwe esingu-40:1, futhi uhlele umthamo wansuku zonke ongaguquguquki. Uma uhlangabezana nanoma yimiphi imiphumela emibi, kumelwe uyeke ukuthatha lezi zengezo bese uthintana nodokotela wakho ukuze uthole iseluleko sochwepheshe.

Imibuzo evame ukubuzwa

1. Yisiphi isikhathi esingcono kakhulu sokuthatha i-myo inositol?

Isikhathi esingcono kakhulu sokuthatha i-myo-inositol noma noma iyiphi enye i-supplement ngesikhathi sokudla. Lokhu kwandisa ukumuncwa kwe-supplement emzimbeni futhi kunikeze imiphumela ephakeme kakhulu.

2. Uyini umehluko phakathi kwe-myo-inositol ne-D chiro inositol?

I-Myo inositol iyifomu elivame kakhulu futhi isekela ukulawulwa kwe-insulin nempilo yamaseli, kanti i-D chiro inositol isebenza kanye nayo ukwandisa ukuzwela kwe-insulin. Uma uyithatha zihlangene, zithuthukisa ukulawulwa kwama-hormone nempilo yokuzala.

3. Iyiphi isilinganiso esifanele se-myo-inositol ku-D chiro inositol?

Iningi lezifundo lincoma isilinganiso esingu-40:1 se-myo-inositol ku-D-chiro inositol, ngoba sifana nokulingana kwemvelo komzimba futhi sinikeza imiphumela ephakeme kakhulu.

Imithombo esetshenzisiwe

1. Gambioli, R., Forte, G., Buzzaccarini, G., Unfer, V., & Laganà, A. S. (2021). I-Myo-Inositol njengomsekeli obalulekile wokuzala nokukhulelwa okujwayelekile. Pharmaceuticals, 14(6), 504. https://doi.org/10.3390/ph14060504 
2. Inositol. (2024, May 1). Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/25173-inositol 
3. Zarezadeh, M., Dehghani, A., Faghfouri, A. H., Radkhah, N., Kermanshahi, M. N., Kalajahi, F. H., Honarvar, N. M., Ghoreishi, Z., Ostadrahimi, A., & Mamaghani, M. E. (2021). Ukuthatha i-inositol njenge-supplement kanye nesilinganiso sesisindo somzimba (BMI). Obesity Science & Practice, 8(3), 387–397. https://doi.org/10.1002/osp4.569 
4. DiNicolantonio, J. J., & O’Keefe, J. H. (2022). I-Myo-inositol ukulwa nokungabekezelelani kwe-insulin, i-metabolic syndrome, i-polycystic ovary syndrome kanye nesifo sikashukela sokukhulelwa. Open Heart, 9(1), e001989. https://doi.org/10.1136/openhrt-2022-001989 
5. DiNicolantonio, J. J., & O’Keefe, J. H. (2022). I-Myo-inositol ukulwa nokungabekezelelani kwe-insulin, i-metabolic syndrome, i-polycystic ovary syndrome kanye nesifo sikashukela sokukhulelwa. Open Heart, 9(1), e001989. https://doi.org/10.1136/openhrt-2022-001989 
6. Kalra, B., Kalra, S., & Sharma, J. B. (2016). Ama-inositol nesifo se-ovary esinezinhlamvu eziningi (polycystic ovary syndrome). Indian Journal of Endocrinology and Metabolism, 20(5), 720. https://doi.org/10.4103/2230-8210.189231 
7. Gambioli, R., Forte, G., Buzzaccarini, G., Unfer, V., & Laganà, A. S. (2021b). I-Myo-Inositol njengomsekeli obalulekile wokuzala nokukhulelwa okujwayelekile. Pharmaceuticals, 14(6), 504. https://doi.org/10.3390/ph14060504 
8. WebMD. (n.d.). Inositol: Ukusetshenziswa, imiphumela emibi, nokunye. Kutholakale ngo-December 7, 2024, ku- https://www.webmd.com/vitamins/ai/ingredientmono-299/inositol 
9. Nordio, M., Basciani, S., & Camajani, E. (2019). Isilinganiso segazi esingu-40:1 se-myo-inositol/D-chiro-inositol siyakwazi ukubuyisela ukuvuthwa kwamaqanda ezigulini ze-PCOS: kuqhathaniswa nezinye izilinganiso. European review for medical and pharmacological sciences, 23(12), 5512–5521. https://doi.org/10.26355/eurrev_201906_18223 
10. Skoracka, K., Ratajczak, A. E., Rychter, A. M., Dobrowolska, A., & Krela-Kaźmierczak, I. (2021). Ukuzala kwabesifazane nendlela yokondleka: Izici ezibaluleke kakhulu. Advances in nutrition (Bethesda, Md.), 12(6), 2372–2386. https://doi.org/10.1093/advances/nmab068 
11. Chang, G., McNamara, T. K., Haimovici, F., & Hornstein, M. D. (2006). Ukuphuza ngokweqile kwabesifazane abahlolwe ukungazali. The American journal on addictions, 15(2), 174–179. https://doi.org/10.1080/10550490500528639