Ama-fatty acid abalulekile ekuthuthukisweni kombungu
Umbuzo owodwa wendabuko kwezofuzo lokuthuthuka ukuthi izinhlobo ezahlukene zezicubu zivela kanjani endaweni efanele embungwini okhulayo. Nakuba umzila owodwa wamasignali olawula le nqubo uchazwe kahle, ukutholakala okungalindelekile kwethimba eliholwa uSteven Farber waseCarnegie kuveza ukubaluleka kokugaywa kwamafutha anama-polyunsaturated fatty acid kule nqubo. Lokhu kushicilelwe ku-inthanethi ngoDisemba 12 ku-Developmental Cell.
Amafatty acid asebenza njengemithombo yamandla, izinto zokwakha zamamembrane amaseli, futhi njengamasignali okudlulisa imiyalezo phakathi kwamaseli. Ama-enzyme ayadingeka ukuze asebenzise amafatty acid akhululekile ukuze abe usizo ezinqubweni zeseli. Ama-enzyme enza lo msebenzi abizwa ngokuthi ama-acyl-CoA synthetase, avame ukufushaniswa ngokuthi ACS.
Ilungu elilodwa lomndeni we-ACS, i-ACSL4, lisebenzisa amafatty acid akhethekile abizwa ngokuthi ama-polyunsaturated fatty acid. Ukuguquka kwe-ACSL4 kuhlotshaniswa nezinkinga zokuthuthuka komzimba kwabantu okuhlanganisa uhlobo lokukhubazeka kwengqondo oluxhunywe ku-X chromosome. Ama-enzyme e-ACSL4 ezilwane ezanyisayo nempukane yezithelo akhonjisiwe ukuthi adlala indima ekuthuthukisweni kobuchopho nasekusindeni kombungu. Nokho, ucwaningo ngezindima ze-ACSL4 yezilwane ezanyisayo ekuthuthukisweni kombungu luphazanyiswe ukulethwa kwamafutha anama-polyunsaturated fatty acid ngumama kumbungu okhulayo, kanye nesidingo samafutha anama-polyunsaturated fatty acid ekutshalweni kombungu nasekuthuthukisweni kwesibeletho.
UFarber nethimba lakhe, okuhlanganisa nomlobi ohola ucwaningo uRosa Miyares, basebenzisane nelabhorethri kaHammerschmidt eNyuvesi yaseCologne eJalimane basebenzisa i-zebrafish ethuthuka ngaphandle komzimba ukuze baqonde ukuthi i-ACSL4 yenzani ngesikhathi sokwakheka kombungu. UMiyares nethimba lakhe bakhombisa ukuthi i-ACSL4 ibaluleke kakhulu ukuze imbewu ithuthuke ibe nombutho wezicubu ohlelekile.
Bakhombisa ukuthi umsebenzi we-enzyme ye-ACSL4 ulawula iprotheni ethile emzileni wamasignali we-Bmp, obalulekile ekuhlelweni okufanele kombungu. “Sesikwazi isikhathi eside ukuthi ama-polyunsaturated fatty acid abalulekile empilweni yangaphambi kokubeletha; e-United States, la mafutha asakazeke kakhulu kumavithamini okubeletha. Ngokuxhumanisa ukugaywa kwamafutha anama-polyunsaturated fatty acid nomzila oyisisekelo wamasignali embungwini wokuqala, ucwaningo lwethu lunikeza umkhondo wokuthi kungani ebaluleke kangaka. Le miphumela ibeka isisekelo socwaningo olwengeziwe ngokugaywa kwamafutha anama-polyunsaturated fatty acid kanye nezinhlobonhlobo zezindima zawo ekuthuthukisweni nasezifo,” kusho uFarber.
Lo msebenzi uxeshelwe yi-NIH, i-Carnegie Institution for Science, i-G. Harold and Leila Y. Mathers Charitable Foundation, i-German Research Foundation, kanye ne-European Union 7th Framework Program Integrated Project.
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Ref.: Funda ngemiphumela emibi yama-fat burner ku-Mr Trim Fit.
